美國波士頓兒童醫(yī)院2024年招聘博士后（細胞表面受體與跨膜信號傳導）
波士頓兒童醫(yī)院，始建于1869年，一家非盈利醫(yī)療機構。
Special Postdoctoral Fellow in Cell Surface Receptors and Transmembrane Signaling
Employer
Springer Lab - PCMM - Boston Children's Hospital
Location
Boston, Massachusetts (US)
Salary
$78,000/annually + benefits
Closing date
11 Jan 2025
Join the Lab of Tim Springer
Tim Springer, a leader in integrin biology, invites aspiring scientists to join his lab to advance groundbreaking research in integrin transmembrane signaling, TGF-β activation, cell surface receptor mechanobiology, and therapeutic development. This role offers mentorship and opportunities to establish a strong scientific foundation for launching an independent research career.
About the Role:
As a Special Postdoctoral Fellow, you will:
Pursue cutting-edge research in areas such as:
Novel integrin ligands to drive stem cell and organoid development
Cryo-EM: Activation of integrins and TGF-β, and ligand binding
Mechanobiology: Integrin force transduction in rolling adhesion and firm adhesion and TGF-β activation
Single Molecules: Utilize advanced techniques including FRET and magnetic tweezers to explore conformational change kinetics and force transmission in integrins and selectins
Innovative ReaLiSM: (Receptor and Ligand in Single Molecules) to study receptor-ligand binding dynamics
TGF-β Activation: Research localized activation at cell surfaces for new therapeutic targets
Own and Develop Your Project: We encourage candidates to propose and develop their own research ideas, which they can carry forward to establish their own labs.
Key Techniques and Approaches:
Single-molecule imaging
Cryo-EM
Organoid and stem cell research
FRET reporters using non-canonical amino acids
Magnetic and laser tweezers
Mechanobiology and therapeutic target discovery
Application Details: To apply, please email the following to springer_jobs@crystal.harvard.edu with "Special Postdoctoral Fellow" in the subject line:
Cover letter (include a brief outline of your project interests)
CV
Three references
Salary: $78,000 annually
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